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1. Early Hum Dev. 2010 Jun 17. [Epub ahead of print]  

The influence of early postnatal nutrition on retinopathy

 of prematurity in extremely low birth weight infants. 

Porcelli PJ, Weaver RG Jr.  Department of Pediatrics, 

Wake Forest University, Winston-Salem, NC, 27157, 

United States; Department of Ophthalmology, Wake 

Forest University, Winston-Salem, NC, 27157, United 

States. 

BACKGROUND: Retinopathy of prematurity(ROP) 

is the most common serious ophthalmic disease in 

preterm infants. Human milk may provide a protective 

effect for ROP; however, beneficial effects of human 

milk preclude randomized trials. Therefore,  we 

conducted a retrospective analysis comparing early 

postnatal nutrition with ROP development. 

OBJECTIVE: Evaluate relationship between early 

postnatal nutriture and ROP surgery. 

DESIGN/METHODS: Nutrition data was collected for inborn

AGA infants, BW 700-1000g. ROP surgery was the primary 

outcome variable. A single pediatric ophthalmologist 

supervised examinations. All infants received triweekly 

IM vitamin A as chronic lung disease prophylaxis (Tyson: 

NEJM, 1999). RESULTS: BW and gestational age were 867+/-85g 

and 26.3+/-1.2weeks (n=77, mean+/-1SD). ROP surgery infants

(n=11) received more parenteral nutrition, 1648mL, and 

less human milk, 13.8mL/kg-day, and vitamin E, 1.4mg/kg-day, 

during the second postnatal week. Human milk was a negative 

predictor for ROP surgery, odds ratio=0.94. Both groups met 

vitamin A recommendations; however, 74% was administered 

via IM injections. Neither group met vitamin E recommendations. 

CONCLUSIONS: Human milk feeding, parenteral nutrition 

volume and vitamin E intake were predictors for ROP surgery. 

IM vitamin A injections provided the majority of vitamin A; 

vitamin E administration was insufficient. Improving human 

milk feeding rates and vitamin dosing options may affect 

ROP surgery rates. Copyright  © 2010 Elsevier Ltd. All rights 

reserved.  PMID: 20561759 [PubMed - as supplied by publisher]