Wednesday, July 7, 2010

PubMed Search Results

PubMed Results
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1. Early Hum Dev. 2010 Jun 17. [Epub ahead of print]  
The influence of early postnatal nutrition on retinopathy
 of prematurity in extremely low birth weight infants. 
Porcelli PJ, Weaver RG Jr.  Department of Pediatrics, 
Wake Forest University, Winston-Salem, NC, 27157, 
United States; Department of Ophthalmology, Wake 
Forest University, Winston-Salem, NC, 27157, United 
BACKGROUND: Retinopathy of prematurity(ROP) 
is the most common serious ophthalmic disease in 
preterm infants. Human milk may provide a protective 
effect for ROP; however, beneficial effects of human 
milk preclude randomized trials. Therefore,  we 
conducted a retrospective analysis comparing early 
postnatal nutrition with ROP development. 
OBJECTIVE: Evaluate relationship between early 
postnatal nutriture and ROP surgery. 
DESIGN/METHODS: Nutrition data was collected for inborn
AGA infants, BW 700-1000g. ROP surgery was the primary 
outcome variable. A single pediatric ophthalmologist 
supervised examinations. All infants received triweekly 
IM vitamin A as chronic lung disease prophylaxis (Tyson: 
NEJM, 1999). RESULTS: BW and gestational age were 867+/-85g 
and 26.3+/-1.2weeks (n=77, mean+/-1SD). ROP surgery infants
(n=11) received more parenteral nutrition, 1648mL, and 
less human milk, 13.8mL/kg-day, and vitamin E, 1.4mg/kg-day, 
during the second postnatal week. Human milk was a negative 
predictor for ROP surgery, odds ratio=0.94. Both groups met 
vitamin A recommendations; however, 74% was administered 
via IM injections. Neither group met vitamin E recommendations. 
CONCLUSIONS: Human milk feeding, parenteral nutrition 
volume and vitamin E intake were predictors for ROP surgery. 
IM vitamin A injections provided the majority of vitamin A; 
vitamin E administration was insufficient. Improving human 
milk feeding rates and vitamin dosing options may affect 
ROP surgery rates. Copyright  © 2010 Elsevier Ltd. All rights 
reserved.  PMID: 20561759 [PubMed - as supplied by publisher]  

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