Wednesday, September 23, 2009

Stimulating sight

Stimulating sight.

Led by electrical engineering professor John Wyatt, team develops retinal
implant that could help restore useful level of vision to certain groups of
blind people

Anne Trafton, MIT News Office, September 23, 2009.

Inspired by the success of cochlear implants that can restore hearing to some
deaf people, researchers at MIT are working on a retinal implant that could one
day help blind people regain a useful level of vision.

The eye implant is designed for people who have lost their vision from retinitis
pigmentosa or age-related macular degeneration, two of the leading causes of
blindness. The retinal prosthesis would take over the function of lost retinal
cells by electrically stimulating the nerve cells that normally carry visual
input from the retina to the brain.

Such a chip would not restore normal vision but it could help blind people more
easily navigate a room or walk down a sidewalk.

"Anything that could help them see a little better and let them identify objects
and move around a room would be an enormous help," says Shawn Kelly, a
researcher in MIT's Research Laboratory for Electronics and member of the Boston
Retinal Implant Project.

The research team, which includes scientists, engineers and ophthalmologists
from Massachusetts Eye and Ear Infirmary, the Boston VA Medical Center and
Cornell as well as MIT, has been working on the retinal implant for 20 years.
The research is funded by the VA Center for Innovative Visual Rehabilitation,
the National Institutes of Health, the National Science Foundation, the Catalyst
Foundation and the MOSIS microchip fabrication service.

Led by John Wyatt, MIT professor of electrical engineering, the team recently
reported a new prototype that they hope to start testing in blind patients
within the next three years.

Electrical stimulation.

Patients who received the implant would wear a pair of glasses with a camera
that sends images to a microchip attached to the eyeball. The glasses also
contain a coil that wirelessly transmits power to receiving coils surrounding
the eyeball.

When the microchip receives visual information, it activates electrodes that
stimulate nerve cells in the areas of the retina corresponding to the features
of the visual scene. The electrodes directly activate optical nerves that carry
signals to the brain, bypassing the damaged layers of retina.

One question that remains is what kind of vision this direct electrical
stimulation actually produces. About 10 years ago, the research team started to
answer that by attaching electrodes to the retinas of six blind patients for
several hours.

When the electrodes were activated, patients reported seeing a small number of
"clouds" or "drops of blood" in their field of vision, and the number of clouds
or blood drops they reported corresponded to the number of electrodes that were
stimulated. When there was no stimulus, patients accurately reported seeing
nothing. Those tests confirmed that retinal stimulation can produce some kind of
organized vision in blind patients, though further testing is needed to
determine how useful that vision can be.

After those initial tests, with grants from the Boston Veteran's Administration
Medical Center and the National Institutes of Health, the researchers started to
build an implantable chip, which would allow them to do more long-term tests.
Their goal is to produce a chip that can be implanted for at least 10 years.

One of the biggest challenges the researchers face is designing a surgical
procedure and implant that won't damage the eye. In their initial prototypes,
the electrodes were attached directly atop the retina from inside the eye, which
carries more risk of damaging the delicate retina. In the latest version,
described in the October issue of IEEE Transactions on Biomedical Engineering,
the implant is attached to the outside of the eye, and the electrodes are
implanted behind the retina.

That subretinal location, which reduces the risk of tearing the retina and
requires a less invasive surgical procedure, is one of the key differences
between the MIT implant and retinal prostheses being developed by other research

Another feature of the new MIT prototype is that the chip is now contained in a
hermetically sealed titanium case. Previous versions were encased in silicone,
which would eventually allow water to seep in and damage the circuitry.

While they have not yet begun any long-term tests on humans, the researchers
have tested the device in Yucatan miniature pigs, which have roughly the same
size eyeballs as humans. Those tests are only meant to determine whether the
implants remain functional and safe and are not designed to observe whether the
pigs respond to stimuli to their optic nerves.

So far, the prototypes have been successfully implanted in pigs for up to 10
months, but further safety refinements need to be made before clinical trials
in humans can begin.

Wyatt and Kelly say they hope that once human trials begin and blind patients
can offer feedback on what they're seeing, they will learn much more about how
to configure the algorithm implemented by the chip to produce useful vision.

Patients have told them that what they would like most is the ability to
recognize faces. "If they can recognize faces of people in a room, that brings
them into the social environment as opposed to sitting there waiting for someone
to talk to them," says Kelly.

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